Epidural clonidine used as an adjunct to area anesthetics has a few different mechanisms of action. First, the stimulation of alpha-2-receptors in the dorsal horn minimizes pain transmission. Secondly, clonidine might cause regional vasoconstriction that limits vascular elimination of regional epidural anesthetics. Jun ten, 2024 · If clonidine therapy https://johnf283low5.shivawiki.com/user