Environmental or self-antigens and homotypic interactions induce BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other alerts through the microenvironment and rising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have identified recurrent mutations in genes regulating tumor cell-microenvironment interactions, which... https://jessew853pyf0.blogolenta.com/profile