DNA ligases seal five′-PO4 and 3′-OH polynucleotide ends via a few nucleotidyl transfer steps involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are essential guardians of genomic integrity, and ligase dysfunction underlies human genetic disease syndromes. Crystal buildings of DNA ligases certain to nucleotide and nucleic acid substrates have illuminated https://ligazbetbest-sports-betti15825.blogminds.com/this-article-is-under-review-25799401