Bad/Comprehensive Metabolizers, CYP2D6 The development from the active metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Approximately 7% from the inhabitants has reduced activity of your CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme method. These people today are “inadequate metabolizers” of debrisoquine, dextromethorphan and tricyclic antidepressants, between ot... https://motherx454eou6.wikicorrespondent.com/user